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Vaughan Brothers ~ Family Style
Stevie Ray Vaughan died in a helicopter crash on August 27, 1990, just as the first single from this CD, the beautiful Motown/soul-inspired workout "Tick Tock," was about to climb the charts and make the blues-rock hero an international superstar. Thankfully, he was able to make this delightful and laid-back album with his brother. For Jimmie and Stevie Ray, it was a kind of spiritual reunion. Jimmie had followed Stevie down the path to sobriety. These New York City sessions were a spirited celebration intended to mark the beginning of their musical partnership. While some tunes sound like the result of mere jamming, "Telephone Song" is one of Stevie's best numbers: an elegant blues shout with screaming guitar breaks. And Jimmie's B-3 organ-like textures on steel guitar astound. --Ted Drozdowski
Open access journal of the Ferrata-Storti Foundation, a non-profit organization
Open access journal of the Ferrata-Storti Foundation, a non-profit organization
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This open-label, single-arm study investigated the long-term efficacy of tafasitamab plus lenalidomide in 81 patients with relapsed/refractory diffuse large B-cell lymphoma. The response rate was 57.5%, including complete responses in 40.0% of patients, and the median duration of response was 43.9 months. This treatment is a valuable option for patients not eligible for autologous stem-cell transplantation.
Grey zone lymphoma is a B-cell lymphoma, unclassifiable, with features intermediate between those of large B-cell lymphoma and classic Hodgkin lymphoma. The in-depth study of the two adolescent patients described in this case report expands the clinicopathological and genomic spectrum of this rare pediatric disease. Moreover, it provides information on their response to treatment.
The clinical picture of 56 patients with congenital amegakaryocytic thrombocytopenia due to MPL mutations was much more varied than previously thought. Twenty-five per cent of them had no signs of thrombocytopenia at birth, and 50% had non-hematologic defects. Pancytopenia developed in (nearly) all patients and hematopoietic stem-cell transplantation was effective in 87% of cases.
Sickle red blood cells exhibit abnormal adhesion to laminin mediated by Lu/BCAM protein at their surface. This study provides evidence of the involvement of oxidative stress in post-translational modifications of Lu/BCAM which impact the protein’s distribution and cis-interaction with glycophorin C at the cell surface activating its adhesive function in dense sickle red cells. The authors speculate that antioxidant drugs might attenuate this phenomenon.